Thursday, February 7, 2008

agressive diabetes treatment causing more deaths

february 7 2008

Another large diabetes study has been put (partially) to a halt because of too many deaths.

Don't worry, None of the diabetes guidelines are changed.

The study, dubbed Accord (Action to Control Cardiovascular Risk in Diabetes), involved 10251 diabetics with heart disease or other high-risk conditions.
The researchers wanted to answer the questions whether below-normal levels would result in less disease and casualties.

The result now, 18 months before the scheduled end of the study, the researchers have found 257 deaths among aggressively treated patients compared to 203 among diabetics given more standard care.

The study showed very interesting results.

The death rate of the study was well below what doctors usually see in Type 2 diabetics. An effects which can be expected, as people received extra care and monitoring received as part of the research.

And even better: the intensive treated patients suffered about 10 percent fewer heart attacks overall than their counterparts.

But when a heart attack occured it was fatal in more cases.
And there were more unexpected sudden deaths, even without a clear heart attack, in this group.

Ofcourse risk factors were taken into account, like hypoglycemia (too low blood sugar levels), use of the drug Avandia that is suspected of being heart-risky.
But it showed that these factors were not the cause.

Right now the researchers are studying all individual cases trying to find an explanation.

Diabetes patiƫnts have several ways of controling their blood sugar level: selfcontrol, measuring the actual blood glucose level, and labcontrol, measuring A1C, also called HbA1c.

The HbA1c blood test estimates how well blood sugar has been controlled during the previous three to four months.

The HbA1c test measures the percentage of hemoglobin molecules in the red blood cells that have glucose attached. Since red blood cells last an average of four months before the body makes new blood cells, this test can indicate the average blood glucose levels over the life span of the blood cells being tested.

Normal ranges vary slightly depending on the laboratory being used.
HbA1c is expressed as a percentage and in general the non-diabetic range is 4 percent to 6 percent.

The American Diabetes Association has set age appropriate targets for HbA1c, which include:

For children under age six, the target is 7.5 percent to 8.5 percent
For six to 12 year olds, the target is under 8 percent
For teens age 13 to 19, the target is under 7.5 percent
For adults, the target is under 7 percent

So you see that the target gives a margin between the topnormal level of healthy individuals and the topnormal level of diabetics.

The study aimed for blood sugars in the low normal area of healthy individuals.
Th reason is that lowering blood sugar levels results in less short term and long term complications.

I'm one of the millions of diabetespatients on this world.
For a long time I've been able to keep my Hba1C at 5.6 which is rather low for a diabetespatiƫnt.
I didn't feel well, however. I was always tired, stressed, my life was based on a strickt schedule of meals and exercise.
And even though my doctors were very happy and I was living healthy, my cholesterol levels were climbing, my bloodpressure was climbing and I experienced problems with bodytemperature control, extreme hunger, dizziness and some other problems, some describe to too low blood sugars.
I was lucky I had no job, otherwise I wouldn´t have been able to cope.

When I couldn't tolerate the side effects anymore, I just pushed aside the schedule of meals and hunger and started to eat when I saw fit. Carefully monitoring the blood sugar levels.
I tried to keep them as stabile as possible during the day.
Eating to need instead of schedule resulted in less blood sugar peaks. And more interesting, it also resulted in a lowering of the cholesterol levels and more feelings of wellbeing. I felt more energetic.

Ofcourse I´m just one person. But I've talked with a lot of other diabetics and many have the same experience.

Diabetes is a signal of a body not cooping with normal food.
I'm sure diabetes isn't the disease, it's the signal.
Agressively treating the signal might put the underlying unknown disease under such a pressure that harm is caused to the body too.
Just an hypothesis.

Time will tell why these people died while taking part in this research.
My feelings go out to the family.
These people were brave and courageous to take part in a study.

I'm sure they haven't died for nothing.

1 comment:

  1. nice information, i have bookmarked this page and i will check other articles too.thanks for sharing


Thank you for your comment.